An injectable and self-healing hydrogel with dual physical crosslinking for in-situ bone formation. Tao Yu, Yunping Hu, Wenbao He, Yong Xu, Anqi Zhan, Kai Chen, Mingxiang Liu, Xiufeng Xiao, Xiangyang Xu, Qian Feng, Liangfu Jiang.ACS Applied Materials & Interfaces 2022, 14 Precisely Tuning the Pore-Wall Surface Composition of Bioceramic Scaffolds Facilitates Angiogenesis and Orbital Bone Defect Repair. Yiyu Peng, Jingyi Wang, Xizhe Dai, Menglu Chen, Zhaonan Bao, Xianyan Yang, Jiajun Xie, Changjun Wang, Ji Shao, Haijie Han, Ke Yao, Zhongru Gou, Juan Ye.
This article is cited by 16 publications. Overall, our investigations revealed the efficacy of Ca–P–Mg scaffolds in healing orbital bone defects and warrant further exploration of these scaffolds for clinical applications. Furthermore, the scaffolds trigger trigeminal neurons via transient receptor potential vanilloid subtype 1 (Trpv1) to produce the neuropeptide calcitonin gene-related peptide (CGRP), which promotes angiogenesis and osteogenesis. In addition, the increased angiogenesis including increased ratio of the specific endothelial subtype CD31 hi endomucin hi (CD31 hiEmcn hi) endothelial cells can facilitate osteogenesis.
The scaffolds robustly enhanced bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation. The osteogenic and ancillary cells, including vascular endothelial cells and trigeminal neurons, played important roles in this process. At 6 months after transplanting the scaffolds to a clinically relevant canine large animal model, large-sized defects were successfully bridged by an abundance of new bone with normal mechanical properties that corresponded to gradual degradation of the implants. In this study, via alloying, extrusion and surface modification, we developed mechanobiologically optimized magnesium (Mg) scaffolds (Ca–P-coated Mg–Zn–Gd scaffolds, referred to as Ca–P–Mg) for the orthotopic reconstruction of large-sized orbital bone defects. The treatment of orbital bone defects is currently palliative and not reparative, suggesting an urgent demand for biomaterials that regenerate orbital bones. Large-sized orbital bone defects have serious consequences that destroy orbital integrity and result in maxillofacial deformities and vision loss.
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